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HelpTest Code ALPS Alpha Beta Double-Negative T Cells for Autoimmune Lymphoproliferative Syndrome, Blood
Reporting Name
ALPS ScreenUseful For
Diagnosing autoimmune lymphoproliferative syndrome, primarily in patients younger than 45 years
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Whole Blood EDTAShipping Instructions
Testing is performed Monday through Friday. Specimens not received by 4pm (CST) on Friday may be canceled.
Collect and package specimen as close to shipping time as possible. It is recommended that specimens arrive within 24 hours of collection.
Samples arriving on the weekend and observed holidays may be canceled.
Necessary Information
Ordering healthcare professional name and phone number are required.
Specimen Required
Container/Tube: Lavender top (EDTA)
Specimen Volume: 3 mL
Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.
Additional Information: For serial monitoring, it is recommended that specimens are collected at the same time of day.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole Blood EDTA | Ambient | 72 hours | PURPLE OR PINK TOP/EDTA |
Reference Values
Alpha beta TCR+DNT cells
2-18 years: <2% CD3 T cells
19-70+ years: <3% CD3 T cells
Reference values have not been established for patients that are younger than 24 months of age.
Alpha beta TCR+DNT cells
2-18 years: <35 cells/mcL
19-70+ years: <35 cells/mcL
Reference values have not been established for patients that are younger than 24 months of age.
Alpha beta TCR+DNT B220+ cells
2-18 years: <0.4% CD3 T cells
19-70+ years: <0.3% CD3 T cells
Reference values have not been established for patients that are younger than 24 months of age.
Alpha beta TCR+DNT B220+ cells
2-18 years: <7 cells/mcL
19-70+ years: <6 cells/mcL
Reference values have not been established for patients that are younger than 24 months of age.
TCR = T-cell receptor
DNT = Double negative T cell
Day(s) Performed
Monday through Friday
Test Classification
This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
86356 x2
86359
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ALPS | ALPS Screen | 101414-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 23973 | %alpha/beta-TCR DNT | 34962-1 |
| 23974 | alpha/beta-TCR DNT | 34963-9 |
| 28904 | % TCR+DNT B220+ | 88052-6 |
| 28905 | Absolute TCR+DNT B220+ | 88053-4 |
| 23975 | Interpretation | 69052-9 |
Report Available
3 to 4 daysMethod Name
Flow Cytometry
Forms
If not ordering electronically, complete, print, and send a Benign Hematology Test Request Form (T755) with the specimen.