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HelpTest Code KLHCS Kelch-Like Protein 11 Antibody, Cell Binding Assay, Serum
Specimen Required
Patient Preparation: For optimal antibody detection, specimen collection is recommended before starting immunosuppressant medication or intravenous immunoglobulin (IVIg) treatment.
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Useful For
Positivity for Kelch-like protein 11 (KLHL11)-IgG is indicative of a paraneoplastic neurological syndrome. Positivity indicates a high likelihood of finding a testicular cancer. A rigorous search for cancer should be initiated after KLHL11 autoimmunity is confirmed.
Testing Algorithm
If the cell binding antibody result is reactive, then the immunofluorescence titer assay will be performed at an additional charge.
Method Name
Cell-Binding Assay (CBA)
Reporting Name
KLHL11-IgG CBA, SSpecimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 28 days |
| Frozen | 28 days | |
| Ambient | 72 hours |
Reference Values
Negative
Day(s) Performed
Monday through Sunday
Report Available
3 to 5 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
0432U
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| KLHCS | KLHL11-IgG CBA, S | 99072-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 622117 | KLHL11-IgG CBA, S | 99072-1 |