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Test Code MSH2 MSH2 Immunostain, Technical Component Only


Ordering Guidance


This test includes only technical performance of the stain (no pathologist interpretation is performed).

 

For immunostain detection of MLH1 protein without interpretation, order MLH1 / MLH1 Immunostain, Technical Component Only.

 

For immunostain detection of MSH6 protein without interpretation, order MSH6 / MSH6 Immunostain, Technical Component Only.

 

For immunostain detection of PMS2 protein without interpretation, order PMS2 / PMS2 Immunostain, Technical Component Only.

 

For immuno stain detection of MLH1, MSH2, MSH6, and PMS2 for miscellaneous tumors without interpretation, order IHC / Mismatch Repair (MMR) Protein Immunohistochemistry Only, Tumor.

 

For interpretation and diagnosis of submitted pathology specimens with appropriate additional stains and other ancillary testing, order PATHC / Pathology Consultation.

 

Additional material may be needed if alternative testing is requested. See the specific specimen requirements for the alternative requested testing.



Shipping Instructions


Attach the green "Attention Pathology" address label (T498) and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.

 



Necessary Information


If sending both normal and tumor blocks; indicate the block number to be stained in performing lab notes (electronic orders) or on the enclosed paperwork (manual orders).



Specimen Required


Specimen Type: Tissue

Supplies: Immunostain Technical Only Envelope (T693)

Container/Tube: Immunostain Technical Only Envelope

Submit:

-Formalin-fixed, paraffin-embedded tissue block

OR

-2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick


Useful For

Identifying patients at high risk for having hereditary nonpolyposis colorectal cancer, also known as Lynch syndrome, in an immunopanel including MSH2 and other mismatch repair markers

 

Evaluation of tumor tissue to identify patients at risk for having hereditary endometrial carcinoma in an immunopanel including MSH2 and other mismatch repair markers

Method Name

Immunohistochemistry (IHC)

Reporting Name

MSH2 IHC, Tech Only

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type Temperature Time
TECHONLY Ambient (preferred)
  Refrigerated 

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

88342-TC, Primary

88341-TC, If additional IHC

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MSH2 MSH2 IHC, Tech Only Order only;no result

 

Result ID Test Result Name Result LOINC Value
70824 MSH2 IHC, Tech Only Bill only; no result

Forms

If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.